Make your selection

List of substances for condition Group: Cognition

All Human Animal Risk/Association ReviewRows: 513

Substance InfoDose WarnLink PubMed
Latest article
Curcumin 📋✍⛔37566247Effect of Curcumin on Cognitive Behavior and Pathological Characteristics of the Hippocampus in Mice with Inherent Alzheimer's Disease
Vitamin D3 📋✍⛔38549749Association of serum vitamin D with anxiety in US adults: a cross-sectional study
Ginsenosides 📋✍⛔38488514Ginsenoside Rk3 Regulates Tryptophan Metabolism along the Brain-Gut Axis by Targeting Tryptophan Hydroxylase and Remodeling the Intestinal Microenvironment to Alleviate Depressive-Like Behavior in Mice
Cannabidiol 📋✍⛔38467272Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models
Melatonin 📋✍⛔38538614Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats
Lavender Essential Oil 📋✍⛔38490827The effect of lavender and bergamot oil applied via inhalation on the anxiety level and sleep quality of surgical intensive care unit patients
Omega-3 Fatty Acids 📋✍⛔38470647Omega-3 Fatty Acids for Depression in the Elderly and Patients with Dementia: A Systematic Review and Meta-Analysis
Resveratrol 📋✍⛔38501767Resveratrol prevents cognitive deficits induced by sleep deprivation via modulating sirtuin 1 associated pathways in the hippocampus
Vitamin C 📋✍⛔38718917Ascorbic acid supplementation improves adolescent stress-induced cognitive impairment through restoration of behavioral, biochemical and electrophysiological alterations in male rats
Saffron 📋✍⛔38068714Effects of Saffron Extract (Affron®) with 100 mg/kg and 200 mg/kg on Hypothalamic-Pituitary-Adrenal Axis and Stress Resilience in Chronic Mild Stress-Induced Depression in Wistar Rats
Quercetin 📋✍⛔38692425Combination of dasatinib and quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice
Crocin 📋✍⛔37688460Integrating serum metabolomics and network analysis to explore the antidepressant activity of crocin in rats with chronic unexpected mild stress-induced depression
Ginseng 📋✍⛔38586351Advancements in research on the effects of panax notoginseng saponin constituents in ameliorating learning and memory disorders
Ashwagandha 📋✍⛔38454585Amelioration by Withania somnifera of neurobehavioural and immunological markers in time dependent sensitization induced post traumatic stress disorder in rats
Berberine 📋✍⛔38318145Research progress on antidepressant effects and mechanisms of berberine
L-Theanine 📋✍⛔37815006Effect of single or combined caffeine and L-Theanine supplementation on shooting and cognitive performance in elite curling athletes: a double-blind, placebo-controlled study
Caffeine 📋✍⛔38542677The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial
Ginkgo Biloba 📋✍⛔38562465Effects and safety of Ginkgo biloba on depression: a systematic review and meta-analysis
Magnesium 📋✍⛔38213402Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials
Luteolin 📋✍⛔37715585Luteolin alleviates depression-like behavior by modulating glycerophospholipid metabolism in the hippocampus and prefrontal cortex of LOD rats
N-Acetyl Cysteine 📋✍⛔38136155Modulation of Kynurenic Acid Production by N-acetylcysteine Prevents Cognitive Impairment in Adulthood Induced by Lead Exposure during Lactation in Mice
Hesperidin 📋✍⛔38107143Hesperidin reduces depressive symptoms in post-coronary artery bypass graft patients with mild depression
Salidroside 📋 38641312Salidroside prevents gestational hypertension-induced impairment of offspring learning and memory via Wnt/Skp2 pathway
Citicoline 📋✍⛔38432442Additive anxiolytic-like effect of citicoline and ACPA in the non-acute restraint stress (NARS) and acute restraint stress (ARS) mice
Gotu Kola 📋✍⛔38703344Hydroalcoholic Extract of Centella asiatica and Madecassic Acid Reverse Depressive-Like Behaviors, Inflammation and Oxidative Stress in Adult Rats Submitted to Stress in Early Life
Micronutrients 📋 ⛔37932977Natural products for the treatment of depression: Insights into signal pathways influencing the hypothalamic-pituitary-adrenal axis
Puerarin 📋✍⛔36039913Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R/BDNF/TrkB signaling
Lemon Balm 📋✍⛔38008959Memory and cognition enhancing effects of combination of Melissa officinalis and Panax ginseng
Baicalin 📋✍⛔37820491Widely targeted metabolomics unveils baicalin-induced hippocampal metabolic alternations in a rat model of chronic unpredictable mild stress
Valerian Root 📋✍⛔33936782The Effects of Valerian on Sleep Quality, Depression, and State Anxiety in Hemodialysis Patients: A Randomized, Double-blind, Crossover Clinical Trial
Apigenin 📋✍⛔37501771Apigenin attenuates depressive-like behavior via modulating monoamine oxidase A enzyme activity in chronically stressed mice
Cocoa 📋✍⛔38268830The effects of dark chocolate on cognitive performance during cognitively demanding tasks: A randomized, single-blinded, crossover, dose-comparison study
Medicinal Plants 📋 36987052Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers
Schisandra 📋✍⛔37992879The physicochemical characteristics and antidepressant-like effects of a polysaccharide-rich fraction from Schisandra chinensis (Turcz.) Baill in behavioral despair mice and olfactory bulbectomy-induced depression-like mice
Vitamin E 📋✍⛔38542534Tocotrienols Prevent the Decline of Learning Ability in High-Fat, High-Sucrose Diet-Fed C57BL/6 Mice
Blueberry 📋✍⛔36357747Blueberry Extract Modulates Brain Enzymes Activities and Reduces Neuroinflammation: Promising Effect on Lipopolysaccharide-Induced Depressive-Like Behavior
EGCG 📋✍⛔38268911(-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation
Acetyl-L-Carnitine 📋✍⛔35721218Synergic action of L-acetylcarnitine and L-methylfolate in Mouse Models of Stress-Related Disorders and Human iPSC-Derived Dopaminergic Neurons
Bergamot Essential Oil 📋✍⛔38553964Bergamot essential oil improves CUMS-induced depression-like behaviour in rats by protecting the plasticity of hippocampal neurons
Chrysin 📋✍⛔38538228Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study
Fish Oil 📋✍⛔37769277Attenuation of Chronic Stress-Induced Depressive-like Symptoms by Fish Oil via Alleviating Neuroinflammation and Impaired Tryptophan Metabolism in Aging Rats
Probiotics 📋✍⛔38404464Mood and microbes: a comprehensive review of intestinal microbiota's impact on depression
Vitamin B12 📋✍⛔37981108Vitamin B12-folic acid supplementation improves memory by altering mitochondrial dynamics, dendritic arborization, and neurodegeneration in old and amnesic male mice
Metformin 📋✍⛔38286229Possible role of metformin as an antidepressant in diabetes
St. Johns Wort 📋✍⛔38684848St. John's wort extract Ze 117 alters the membrane fluidity of C6 glioma cells by influencing cellular cholesterol metabolism
Sulforaphane 📋✍⛔38438062Sulforaphane's role in Redefining autophagic Responses in depression associated with polycystic ovarian syndrome: Unveiling the SIRT1/AMPK/LKB1 pathway connection
Walnut 📋 ⛔37867495Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices
Goji Berry 📋✍⛔38227533Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression: a randomized controlled study
Pomegranate 📋 ⛔37005403Pomegranate and cognitive performance: A systematic review
Thymoquinone 📋 ⛔35718231Effects of thymoquinone on scopolamine-induced spatial and echoic memory changes through regulation of lipid peroxidation and cholinergic impairment
Ellagic Acid 📋✍⛔38291199Oral administration of ellagic acid mitigates perioperative neurocognitive disorders, hippocampal oxidative stress, and neuroinflammation in aged mice by restoring IGF-1 signaling
L-Tryptophan 📋✍⛔36839204Beneficial Effect of Increased Tryptophan Intake on Its Metabolism and Mental State of the Elderly
Selenium 📋✍⛔36547832Selenium attenuates the association of co-exposure to arsenic, cadmium, and lead with cognitive function among Chinese community-dwelling older adults
Dihydromyricetin 📋✍⛔36532369Dihydromyricetin ameliorates social isolation-induced anxiety by modulating mitochondrial function, antioxidant enzymes, and BDNF
Docosahexaenoic Acid 📋✍⛔38136199DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism
Genistein 📋✍⛔37108207Sedative-Hypnotic Effects of Glycine max Merr. Extract and Its Active Ingredient Genistein on Electric-Shock-Induced Sleep Disturbances in Rats
Nigella Sativa 📋✍⛔38379607Black seed oil reverses chronic antibiotic-mediated depression and social behaviour deficits via modulation of hypothalamic mitochondrial-dependent markers and insulin expression
Eicosapentaenoic Acid 📋✍⛔38479498Association between eicosapentaenoic acid consumption and the risk of depressive symptoms in US adults: Analyses from NHANES 2005-2018
Frankincense 📋✍⛔36568722Effect of a Boswellia and Ginger Mixture on the Memory Dysfunction of the Mild Traumatic Brain Injury Patients: A Randomized, Double-Blind Controlled Trial
Green Tea 📋✍⛔38229977Amelioration of nonylphenol-induced anxiety/depression-like behaviors in male rats using green tea and Zn-Se tea interventions
Paeoniflorin 📋 38703807Paeoniflorin exerts anti-PTSD effects in adult rats by modulating hippocampus and amygdala histone acetylation modifications in response to early life stress
Silibinin 📋✍ 38106632Silibinin effects on cognitive disorders: Hope or treatment?
Vitamin B6 📋✍⛔36262766Vitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice
Astaxanthin 📋✍⛔38542737The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans: A Critical Review
Chlorogenic Acid 📋✍⛔37995532Chlorogenic acid improves the cognitive deficits of sleep-deprived mice via regulation of immunity function and intestinal flora
Folate 📋✍⛔37686891Folate and Its Significance in Depressive Disorders and Suicidality: A Comprehensive Narrative Review
Gallic Acid 📋 ⛔38016595Gallic acid ameliorates behavioral dysfunction, oxidative damage, and neuronal loss in the prefrontal cortex and hippocampus in stressed rats
Ginkgolides 📋 37793010Ginkgolide attenuates memory impairment and neuroinflammation by suppressing the NLRP3/caspase-1 pathway in Alzheimer's disease
Holy Basil 📋✍⛔37141281Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic-pituitary-adrenal (HPA) axis in modulating stress
Lycopene 📋✍⛔38054647Lycopene Alleviates Chronic Stress-Induced Hippocampal Microglial Pyroptosis by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway
Magnolia 📋✍⛔33950239A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor
Naringenin 📋✍⛔38561101Liraglutide and Naringenin relieve depressive symptoms in mice by enhancing Neurogenesis and reducing inflammation
Naringin 📋✍⛔36503881Antidepressant-like effect of acute dose of Naringin involves suppression of NR1 and activation of protein kinase A/cyclic adenosine monophosphate response element-binding protein/brain-derived neurotrophic factor signaling in hippocampus
Orange Essential Oil 📋✍⛔34849354Effect of Aromatherapy on Dental Anxiety and Pain in Children Undergoing Local Anesthetic Administrations: A Randomized Clinical Trial
Piperine 📋✍⛔37878284A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study
Rhodiola 📋✍⛔35745023The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence
Rosemary 📋✍⛔37758539The effect of rosemary hydroalcoholic extract on cognitive function and activities of daily living of patients with chronic obstructive pulmonary disease (COPD): A clinical trial
Sage 📋✍⛔35137748Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model
Chamomile Essential Oil 📋✍⛔38172912Effects of aromatherapy with Matricaria chamomile essential oil on anxiety and hemodynamic indices in patients with acute coronary syndrome, 2021: a randomized controlled trial
Geniposide 📋 38232800Geniposide improves depression-like behavior in prenatal stress male offspring through restoring HPA axis- and glucocorticoid receptor-associated dysfunction
Rutin 📋✍⛔38064815Rutin prevents pyroptosis and M1 microglia via Nrf2/Mac-1/caspase-1-mediated inflammasome axis to improve POCD
Skullcap 📋✍⛔38572433The effect of scutellaria baicalensis and its active ingredients on major depressive disorder: a systematic review and meta-analysis of literature in pre-clinical research
Vitamin B Complex 📋 ⛔35714552The role of mixed B vitamin intakes on cognitive performance: Modeling, genes and miRNAs involved
Zinc 📋✍⛔37364014A systematic review of the association between zinc and anxiety
Coffee 📋✍⛔38512715Neurocognitive effects a combined polyphenolic-rich herbal extract in healthy middle-aged adults - a randomised, double-blind, placebo-controlled study
Essential Oils 📋 ⛔37619300Effects of aromatherapy on depression: A meta-analysis of randomized controlled trials
Fisetin 📋✍⛔38168356Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APPNL-F/NL-F Mice
Lipoic Acid 📋✍⛔37898621Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway
Moringa Oleifera 📋✍⛔38633104Comparative Neuroprotective Effects of Moringa oleifera Seed Oil and Aqueous Extract on Cognitive Functions on a High-Fat, High-Fructose Diet Mice: Focus on Senescence Markers
Mulberry 📋 ⛔37597050Morus Alba Fruit Extract and its Fractions Ameliorate Streptozotocin Induced Cognitive Deficit in Mice via Modulating Oxidative and Cholinergic Systems
Olive Oil 📋✍⛔37885446The effects of olive oil consumption on cognitive performance: a systematic review
Polyphenols 📋 38306547Progress of plant polyphenol extracts in treating depression by anti-neuroinflammatory mechanism: A review
Reishi Mushrooms 📋✍⛔36907499Ganoderma lucidum ethanol extract promotes weight loss and improves depressive-like behaviors in male and female Swiss mice
Spikenard 📋✍⛔33220358Antidepressant activities and regulative effects on serotonin transporter of Nardostachys jatamansi DC
Carotenoids 📋✍⛔37467792Plasma carotenoids and risk of depressive symptomatology in a population-based cohort of older adults
CoQ10 📋✍⛔38684047Discovering the Potential Value of Coenzyme Q10 as an Adjuvant Treatment in Patients With Depression
Ferulic Acid 📋✍⛔37869914Psychopharmacological impact of ferulic acid on depressive-like behaviors induced by high fat diet in rats models of depression
Lion's Mane Mushrooms 📋✍⛔38004235The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study
Lutein 📋✍⛔35752349Effect of macular pigment carotenoids on cognitive functions: A systematic review
Nuts 📋 ⛔37542950Nut consumption is associated with a lower risk of depression in adults: A prospective analysis with data from the UK Biobank cohort
Pterostilbene 📋✍⛔38354494Pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male Swiss albino mice and affects insulin resistance, inflammation, HPA axis dysfunction and SIRT1 mediated leptin-ghrelin signaling
Rosemary Essential Oil 📋✍⛔35280245Effect of Aromatherapy Massage on Depression and Anxiety of Elderly Adults: a Randomized Controlled Trial
Rosmarinic Acid 📋✍ 38103880Rosmarinic acid against cognitive impairment via RACK1/HIF-1α regulated microglial polarization in sepsis-surviving mice
Vitamin B9 📋✍⛔37981108Vitamin B12-folic acid supplementation improves memory by altering mitochondrial dynamics, dendritic arborization, and neurodegeneration in old and amnesic male mice
5-HTP 📋✍⛔35572711Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression
Anise 📋✍⛔34451620Assessment of Antidepressant-like, Anxiolytic Effects and Impact on Memory of Pimpinella anisum L. Total Extract on Swiss Albino Mice
Arctigenin 📋 35731324Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice
Astragalosides 📋✍⛔38064688Astragaloside IV Alleviates Depression in Rats by Modulating Intestinal Microbiota, T-Immune Balance, and Metabolome
Choline 📋✍⛔37340479Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: a randomized double-blinded placebo-controlled parallel-group study
Flavonoids 📋 ⛔37890540Dietary flavonoid intake is associated with a lower risk of depressive symptoms in US adults: Data from NHANES 2007-2008, 2009-2010, and 2017-2018
Food 📋 37990906Mediterranean diet-based intervention to improve depressive symptoms: analysis of the PREDIDEP randomized trial
Grape 📋 ⛔35204296Effect of Dietary Grapes on Female C57BL6/J Mice Consuming a High-Fat Diet: Behavioral and Genetic Changes
Green Tea Polyphenols 📋✍⛔34820541The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense
Nobiletin 📋✍ 37432372Nobiletin Mitigates D-Galactose-Induced Memory Impairment via Improving Hippocampal Neurogenesis in Mice
Persimmon 📋 ⛔35668445Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin reuptake in mice
Silymarin 📋✍⛔37429530Silymarin pretreatment protects against ethanol-induced memory impairment: Biochemical and histopathological evidence
Stinging Nettle 📋✍⛔29745257Beneficial effects of Urtica dioica on scopolamine-induced memory impairment in rats: protection against acetylcholinesterase activity and neuronal oxidative damage
Tanshinone 📋 37611463Effects and mechanisms of tanshinone IIA on PTSD-like symptoms
Bacopa Monnieri 📋✍⛔38538390Evaluating the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment: A triple-blinded, randomized, placebo-controlled trial
Baicalein 📋✍⛔37063260Baicalein-corrected gut microbiota may underlie the amelioration of memory and cognitive deficits in APP/PS1 mice
Betaine 📋✍⛔38145759Betaine eliminates CFA-induced depressive-like behaviour in mice may be through inhibition of microglia and astrocyte activation and polarization
Black Pepper 📋✍⛔34778972A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins
Catalpol 📋 37551177Catalpol Alleviates Depression by Inhibiting NLRP3 Inflammasome via TLR4/MAPK/NF-Kb Pathway
Chamomile 📋✍⛔36217471A randomized clinical trial to test efficacy of chamomile and saffron for neuroprotective and anti-inflammatory responses in depressive patients
Coconut Oil 📋 ⛔38106629Assessment of the neuroprotective effect of Cocos nucifera L. oil on learning and behavior impairment in ovariectomized rats
Gardenia 📋 ⛔37377643Fructus gardeniae ameliorates anxiety-like behaviors induced by sleep deprivation via regulating hippocampal metabolomics and gut microbiota
Ginger 📋✍⛔37966694Ginger (Zingiber Officinale Roscoe) ameliorates ethanol-induced cognitive impairment by modulating NMDA and GABA-A receptors in rat hippocampus
Honokiol 📋 37429494BDE-47 flame retardant exposure induces microglial pyroptosis and cognitive deficits by activating the mtROS-NLRP3 axis via Sirt3 downregulation and is salvaged by honokiol
Hydroxytyrosol 📋 38680105Hydroxytyrosol ameliorates stress-induced liver injury through activating autophagy via HDAC1/2 inhibition
Icariin 📋✍ 38552430Icariin mitigates anxiety-like behaviors induced by hemorrhagic shock and resuscitation via inhibiting of astrocytic activation
Indian Gooseberry 📋 ⛔36738163Preventive effect of Indian gooseberry (Phyllanthus emblica L.) fruit extract on cognitive decline in high-fat diet (HFD)-fed rats
Lavender 📋✍⛔35429599The Effect of Lavender on Stress in Individuals: A Systematic Review and Meta-Analysis
Peppermint Essential Oil 📋✍⛔35408451Effects of Peppermint Essential Oil on Learning and Memory Ability in APP/PS1 Transgenic Mice
Prebiotics 📋✍⛔38519181Prebiotics modulate the microbiota-gut-brain axis and ameliorate anxiety and depression-like behavior in HFD-fed mice
Sesamol 📋 37333469Neuroprotective effects of sesamol against LPS-induced spatial learning and memory deficits are mediated via anti-inflammatory and antioxidant activities in the rat brain
Tea 📋 38026433Does frequent tea consumption provide any benefit to cognitive function in older adults? Evidence from a national survey from China in 2018
Zeaxanthin 📋✍⛔35813593The Protective Effects of Zeaxanthin on Amyloid-β Peptide 1-42-Induced Impairment of Learning and Memory Ability in Rats
Andrographolide 📋 36029454Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer's Disease
Asiaticoside 📋 32705202Asiaticoside produces an antidepressant‑like effect in a chronic unpredictable mild stress model of depression in mice, involving reversion of inflammation and the PKA/pCREB/BDNF signaling pathway
Bee Propolis 📋✍⛔37579320Propolis prevents vascular endothelial dysfunction by attenuating inflammation and oxidative damage in the chronic unpredictable stress model of depression in rats
Beta-Glucan 📋✍⛔38142848Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice
Boswellic Acid 📋✍⛔349268583-O-Acetyl-11-keto-β-boswellic acid ameliorates acquired, consolidated and recognitive memory deficits through the regulation of hippocampal PPAR γ, MMP9 and MMP2 genes in dementia model
Carvacrol 📋✍⛔36249457Carvacrol attenuated neuroinflammation, oxidative stress and depression and anxiety like behaviors in lipopolysaccharide-challenged rats
Chokeberry 📋✍⛔38656355Short-term Aronia melanocarpa extract supplementation improves cognitive performance: a randomized, double-blind, placebo-controlled cross-over study in healthy young adults
Crocetin 📋 37935859Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes
DHEA 📋✍⛔38183866Cortisol and changes in depressive symptoms: The moderating role of DHEA
Formononetin 📋 37403720[Formononetin improves cognitive behavior in aging rats with chronic unpredictable mild in hippocampal tissue stress by blocking the NF-κB pathway and inhibiting the release of inflammatory factors]
Fucoidan 📋✍⛔36174863Fucoidan ameliorates LPS-induced neuronal cell damage and cognitive impairment in mice
Geraniol 📋 38517361Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model
Grape Seed extract 📋✍⛔35411989Protective effect of grape seed extract against chronic physical stress-induced zona fasciculata injury in male rats: Functional, immunohistochemical and electron microscopic study
Neroli Essential Oil 📋✍⛔37684883Effects of Aroma Inhalation Therapy on Stress, Anxiety, Depression, and the Autonomic Nervous System in High-risk Pregnant Women
NMN 📋✍⛔37931707Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice
PEA 📋✍⛔38398813Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial
Phytochemicals 📋 37371407Review of Plant Extracts and Active Components: Mechanisms of Action for the Treatment of Obesity-Induced Cognitive Impairment
Sage Essential Oil 📋 ⛔32549250Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice
Salvianolic Acid 📋 37258428Salvianolic Acids Alleviate Chronic Mild Stress-Induced Depressive-Like Behaviors in Rats
Sea Buckthorn 📋✍⛔37485660Flavonoids from Seabuckthorn ( Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice
Spirulina 📋✍⛔36330789Dietary intake of Spirulina platensis alters HSP70 gene expression profiles in the brain of rats in an experimental model of mixed stress
Tangeretin 📋 36216079Tangeretin prevents cognitive deficit in delirium through activating RORα/γ-E4BP4 axis in mice
Taurine 📋✍⛔38302509Integrating transcriptomics and metabolomics to elucidate the mechanism by which taurine protects against DOX-induced depression
Aged Garlic 📋✍⛔32051390Effect of combined extracts of aged garlic, ginger, and chili peppers on cognitive performance and brain antioxidant markers in Aβ-induced rats
Alpha-Linolenic Acid 📋✍⛔38435630Alpha-Linolenic Acid Ameliorates Cognitive Impairment and Liver Damage Caused by Obesity
Angelica 📋✍⛔38154524Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice
Anthocyanins 📋✍⛔38455191Higher anthocyanin intake is associated with lower depressive symptoms in adults with and without major depressive disorder
Basil 📋✍⛔36185698A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (HolixerTM) on stress, mood, and sleep in adults experiencing stress
Bilobalide 📋 37615035Suppressive effects of bilobalide on depression-like behaviors induced by chronic unpredictable mild stress in mice
Casein Protein 📋✍⛔37867495Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices
Cinnamaldehyde 📋 36432096Anxiolytic-like Effect of Inhaled Cinnamon Essential Oil and Its Main Component Cinnamaldehyde in Animal Models
Creatine 📋✍⛔38542677The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial
Echinacea 📋✍⛔31876052Double-blind Placebo Controlled Trial of the Anxiolytic Effects of a Standardized Echinacea Extract
Echinacoside 📋 38547621Echinacoside ameliorates post-stroke depression by activating BDNF signaling through modulation of Nrf2 acetylation
Eugenol 📋 38444813Protective role of Eugenol against the destructive effects of lead on conditioned fear memory in male rats with post-traumatic stress disorder-related behavioral traits
Fenugreek 📋✍⛔32441668Efficacy of Fenugreek Seed Extract on Men's Psychological and Physical Health: A Randomized Placebo-Controlled Double-Blind Clinical Trial
Fish 📋 ⛔37820872How fish consumption prevents the development of Major Depressive Disorder? A comprehensive review of the interplay between n-3 PUFAs, LTP and BDNF
Flaxseed Oil 📋✍⛔36986229Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults
Ganoderic Acid 📋 38723681Ganoderic acid A ameliorates depressive-like behaviors in CSDS mice: Insights from proteomic profiling and molecular mechanisms
Garlic 📋✍⛔38563400The association between raw garlic consumption and the risk of depressive symptoms: the TCLSIH cohort study
Giloy 📋✍⛔35966795Dietary Supplementation With Tinospora cordifolia Improves Anxiety-Type Behavior and Cognitive Impairments in Middle-Aged Acyclic Female Rats
Indian Mulberry 📋✍⛔36765376Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy
Irisin 📋 38408409Aerobic exercise attenuates LPS-induced cognitive dysfunction by reducing oxidative stress, glial activation, and neuroinflammation
L-Carnitine 📋✍⛔36200160The Protective role of L-carnitine on Psychosocial Stress-induced changes in Gene Expression and Protein levels of Matrix Metalloproteinases, Serum Corticosterone in a Rat Model
Licorice Root 📋✍⛔38074876Antidepressant effect of licorice total flavonoids and liquiritin: A review
Morin 📋 38409930Morin improves learning and memory in healthy adult mice
Nicotinamide Riboside 📋✍⛔35585298Acute Treatment with Nicotinamide Riboside Chloride Reduces Hippocampal Damage and Preserves the Cognitive Function of Mice with Ischemic Injury
Oats 📋 ⛔36657906Effect of Avena sativa (Oats) on cognitive function: A systematic review of randomized controlled trials
Patchouli 📋✍⛔38419848Pogostemon cablin essential oil affects anxiety- and depressive-like behaviors and the gut microbiota in chronic unpredictable mild stress model rats
SAMe 📋✍⛔38423354Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: A systematic review and meta- analysis
Scutellarin 📋 35964195Scutellarin Modulates the Microbiota-Gut-Brain Axis and Improves Cognitive Impairment in APP/PS1 Mice
Yiang Yiang Essential Oil 📋 ⛔35551977Ylang-ylang (Cananga odorata (Lam.) Hook. f. & Thomson) essential oil reduced neuropathic-pain and associated anxiety symptoms in mice
Almond 📋 ⛔32575387Snacking on Whole Almonds for Six Weeks Increases Heart Rate Variability during Mental Stress in Healthy Adults: A Randomized Controlled Trial
Antioxidants 📋 ⛔38578890Association Between Composite Dietary Antioxidant Index and Cognitive Function Among Aging Americans from NHANES 2011-2014
Asiatic Acid 📋 33802221Asiatic Acid Prevents Cognitive Deficits by Inhibiting Calpain Activation and Preserving Synaptic and Mitochondrial Function in Rats with Kainic Acid-Induced Seizure
BCAA 📋✍⛔34845278Branched-chain amino acids govern the high learning ability phenotype in Tokai high avoider (THA) rats
Beta-Carotene 📋✍⛔35548582Associations of Dietary Vitamin A and Beta-Carotene Intake With Depression. A Meta-Analysis of Observational Studies
Black Tea 📋✍⛔34795745Effects of black tea consumption and caffeine intake on depression risk in black tea consumers
Burdock 📋 ⛔344395291,3-Dicaffeoylquinic Acid as an Active Compound of Arctium lappa Root Extract Ameliorates Depressive-Like Behavior by Regulating Hippocampal Nitric Oxide Synthesis in Ovariectomized Mice
Carnosic Acid 📋 36331794Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2/HO-1 Pathway
Catechins 📋 36150679(-)-Epicatechin mitigates anxiety-related behavior in a mouse model of high fat diet-induced obesity
Cinnamon 📋✍⛔38696678Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice
Coconut 📋 ⛔27770304Involvement of monoaminergic systems in anxiolytic and antidepressive activities of the standardized extract of Cocos nucifera L
Cordycepin 📋 38294969Dose-dependent action of cordycepin on the microbiome-gut-brain-adipose axis in mice exposed to stress
Cordyceps 📋✍⛔36521708Cordyceps militaris acidic polysaccharides improve learning and memory impairment in mice with exercise fatigue through the PI3K/NRF2/HO-1 signalling pathway
Coriander Essential Oil 📋✍⛔37627529Direct Evidence for Using Coriandrum sativum var. microcarpum Essential Oil to Ameliorate Scopolamine-Induced Memory Impairment and Brain Oxidative Stress in the Zebrafish Model
Dihydroquercetin 📋 38694040Pharmacological investigation of taxifolin for its therapeutic potential in depression
GABA 📋✍⛔38321713GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial
Geranium Essential Oil 📋 ⛔32888828Comparing the effects of geranium aromatherapy and music therapy on the anxiety level of patients undergoing inguinal hernia surgery: A clinical trial
Glycyrrhizic Acid 📋✍⛔38453099Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1/2-dependent pathways
Inulin 📋✍⛔38376033Inulin alters gut microbiota to alleviate post-stroke depressive-like behavior associated with the IGF-1-mediated MAPK signaling pathway
Krill Oil 📋✍⛔37564375Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice
Kudzu Root 📋✍⛔31752523Puerariae Radix Prevents Anxiety and Cognitive Deficits in Mice Under Oligomeric Aβ-Induced Stress
L-Arginine 📋✍⛔35498050L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults
L-Leucine 📋✍⛔37358784Revealing the role of leucine in improving the social avoidance behavior of depression through a combination of untargeted and targeted metabolomics
Lactobacillus plantarum 📋 ⛔26620542Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice
Linalool 📋 ⛔34544345Linalool as a Therapeutic and Medicinal Tool in Depression Treatment: A Review
Magnolol 📋 38183534The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice
Mangiferin 📋 ⛔37376018The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment
Mushrooms 📋 ⛔38337638The Relationship between Mushroom Intake and Cognitive Performance: An Epidemiological Study in the European Investigation of Cancer-Norfolk Cohort (EPIC-Norfolk)
Myricetin 📋 ⛔36302617Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brain via regulation of brain-derived neurotropic factor
Nicotinamide 📋✍⛔37775016Nicotinamide, an acetylcholinesterase uncompetitive inhibitor, protects the blood‒brain barrier and improves cognitive function in rats fed a hypercaloric diet
Orange 📋 ⛔36615801Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial
Peony 📋 ⛔37474737Enhanced neuronal activity by suffruticosol A extracted from Paeonia lactiflora via partly BDNF signaling in scopolamine-induced memory-impaired mice
Pine Bark 📋✍⛔38299491Pycnogenol® improves cognitive function in post-stroke patients: a 6 month-study
Polydatin 📋✍ 36802487Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model
Pumpkin Seed 📋✍⛔37006627Cucurbita maxima Seeds Reduce Anxiety and Depression and Improve Memory
Punicalagin 📋✍⛔35600992Pomegranate and Its Components, Punicalagin and Ellagic Acid, Promote Antidepressant, Antioxidant, and Free Radical-Scavenging Activity in Ovariectomized Rats
Roselle 📋✍⛔36436183Hibiscus sabdariffa (Roselle) calyx: a systematic and meta-analytic review of memory-enhancing, anti-neuroinflammatory and antioxidative activities
Soy Isoflavones 📋✍⛔37009142Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination
Thyme 📋✍⛔38039009Effects of orally administered Thymus vulgaris leaves on memory, anxiety, depression, and sleep quality in university students: a randomized controlled trial
Vitamin B1 📋✍⛔38367708Association between thiamine intake and depression: A national cross-sectional study
Vitamin B2 📋✍⛔38037028Association of vitamin B2 intake with cognitive performance in older adults: a cross-sectional study
Acai Berry 📋✍⛔36405951Açaí ( Euterpe oleracea) pulp-enriched diet induces anxiolytic-like effects and improves memory retention
Allicin 📋✍⛔31201726Allicin Ameliorates Obesity Comorbid Depressive-Like Behaviors: Involvement of the Oxidative Stress, Mitochondrial Function, Autophagy, Insulin Resistance and NOX/Nrf2 Imbalance in Mice
Aloe Vera 📋✍⛔33879444Anxiolytic and memory enhancing potential of aloe vera and flax seed oil in rats: A comparative study with valproic acid
Aspirin 📋 ⛔37509038A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice
Astragalin 📋 35984596Astragalin alleviates cognitive deficits and neuronal damage in SAMP8 mice through upregulating estrogen receptor expression
Astragalus Root 📋✍⛔38301982Antidepressant potential of total flavonoids from Astragalus in a chronic stress mouse model: Implications for myelination and Wnt/β-catenin/Olig2/Sox10 signaling axis modulation
Basil Essential Oil 📋✍⛔28823898Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice?
Beets 📋✍⛔37875637Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial
Biochanin A 📋 35338989Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice
Blackcurrant 📋✍⛔38716086Effects of a Flavonoid-Rich Blackcurrant Beverage on Markers of the Gut-Brain Axis in Healthy Females: Secondary Findings From a 4-Week Randomized Crossover Control Trial
Cardamom 📋✍⛔36781058Cardamom oil ameliorates behavioral and neuropathological disorders in a rat model of depression induced by reserpine
Chlorella 📋✍⛔36118772Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice
Chrysanthemum 📋✍⛔37520324Anxiolytic effects of Chrysanthemum morifolium Ramat Carbonisata-based carbon dots in mCPP-induced anxiety-like behavior in mice: a nature-inspired approach
Cinnamon Essential Oil 📋✍⛔36432096Anxiolytic-like Effect of Inhaled Cinnamon Essential Oil and Its Main Component Cinnamaldehyde in Animal Models
D-Limonene 📋✍⛔33564342Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress
Daidzein 📋✍⛔37619620Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies
Diosgenin 📋 37663254Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress
Diosmin 📋✍⛔38092305Diosmin ameliorates LPS-induced depression-like behaviors in mice: Inhibition of inflammation and oxidative stress in the prefrontal cortex
Essential Fatty Acids 📋✍ 32917237Important considerations when assessing the effect of essential fatty acids on cognitive performance
Fermented Foods 📋 ⛔36900437Fermented Wheat Germ Alleviates Depression-like Behavior in Rats with Chronic and Unpredictable Mild Stress
Frankincense Essential Oil 📋 ⛔31582666The Effects of Frankincense Essential Oil on Stress in Rats
Fruits 📋 37918179Higher fresh fruit intake relates to larger grey matter volumes in areas involved in dementia and depression: A UK Biobank study
Fucoxanthin 📋✍⛔37639810Fucoxanthin, a marine derived carotenoid, attenuates surgery-induced cognitive impairments via activating Akt and ERK pathways in aged mice
Galangin 📋 35718493[Galangin alleviates learning and memory impairments in APP/PS1 double- transgenic mice by regulating Akt/MEF2D/Beclin-1 signaling pathway]
Grapefruit Essential Oil 📋✍⛔33463729Effects of diffused essential oils for reducing stress and improving mood for clinical nurses: An interventional time series study
Haritaki 📋✍⛔37493534Comparative effects of the alcoholic extract of Terminalia chebula and crocin on stress‑induced anxiety‑like behavior and memory impairment in male rats
Hesperetin 📋 37382831Hesperetin attenuates cognitive dysfunction via SIRT6/NLRP3 pathway in scopolamine-induced mice
Honey 📋✍⛔36733498Honey on brain health: A promising brain booster
Hyperoside 📋 36556951The Role and Mechanism of Hyperoside against Depression-like Behavior in Mice via the NLRP1 Inflammasome
Kaempferol 📋✍⛔38587532Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice
Lingonberry 📋 ⛔26738388[Effects of lingonberry extraction on the mice cognitive function damaged by chronic stress]
Maitake Mushrooms 📋 ⛔32450016A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice
Marjoram Essential Oil 📋 ⛔38045619Inhalation of Origanum majorana L. essential oil while working reduces perceived stress and anxiety levels of nurses in a COVID-19 intensive care unit: a randomized controlled trial
Matcha Tea 📋 36771286Matcha Tea Powder's Antidepressant-like Effect through the Activation of the Dopaminergic System in Mice Is Dependent on Social Isolation Stress
Nootkatone 📋 36401752Nootkatone Improves Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors by Repressing NF-κB/NLRP3-Mediated Neuroinflammation
Oleanolic Acid 📋 37812895Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice
Ollive Leaf extract 📋✍⛔34127683Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice
Paeonol 📋 35001353Paeonol Ameliorates Cuprizone-Induced Hippocampal Demyelination and Cognitive Deficits through Inhibition of Oxidative and Inflammatory Events
Pau d'Arco 📋✍⛔24236576NMDA receptors and the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway are implicated in the antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice
Phellodendron 📋✍⛔18426577Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial
Phosphatidylserine 📋✍⛔18481547Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine
Pomegranate Peel extract 📋✍⛔32430240Pomegranate-derived anthocyanin regulates MORs-cAMP/CREB-BDNF pathways in opioid-dependent models and improves cognitive impairments
PUFA 📋 32717402Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems
Quercitrin 📋 35594435Quercitrin improved cognitive impairment through inhibiting inflammation induced by microglia in Alzheimer's disease mice
Safranal 📋 36557792Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis
Schisandrins 📋 36176456Schisandrin alleviates the cognitive impairment in rats with Alzheimer's disease by altering the gut microbiota composition to modulate the levels of endogenous metabolites in the plasma, brain, and feces
Spearmint 📋 ⛔30802720The attention-enhancing effects of spearmint extract supplementation in healthy men and women: a randomized, double-blind, placebo-controlled, parallel trial
Syringic Acid 📋 32040015Morus nigra leaves extract revokes the depressive-like behavior, oxidative stress, and hippocampal damage induced by corticosterone: a pivotal role of the phenolic syringic acid
Thymol 📋✍⛔35668569Thymol mitigates cadmium-induced behavioral and cognitive deficits by up-regulating hippocampal BDNF levels in rats
Trans-Resveratrol 📋 26946512Piperine potentiates the effects of trans-resveratrol on stress-induced depressive-like behavior: involvement of monoaminergic system and cAMP-dependent pathway
TUDCA 📋✍⛔30986644Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice
Vitamin B3 📋✍⛔37723526Dietary niacin intake in relation to depression among adults: a population-based study
Acacetin 📋 36382256Acacetin improves cognitive function of APP/PS1 Alzheimer's disease model mice via the NLRP3 inflammasome signaling pathway
Andrographis 📋✍⛔37301417Antidepressant evaluation of Andrographis paniculata Nees extract and andrographolide in chronic unpredictable stress zebrafish model
Anethole 📋 32491286Protective effect of fennel, and its major component trans-anethole against social isolation induced behavioral deficits in rats
Anthocyanidins 📋 37474898Association between dietary anthocyanidins intake and depression among US adults: a cross-sectional study (NHANES, 2007-2010 and 2017-2018)
Apple 📋 ⛔35167638Apple phenolic extracts ameliorate lead-induced cognitive impairment and depression- and anxiety-like behavior in mice by abating oxidative stress, inflammation and apoptosis via the miR-22-3p/SIRT1 axis
Apple Polyphenols 📋 ⛔38406886Apple polyphenol extract ameliorates sugary-diet-induced depression-like behaviors in male C57BL/6 mice by inhibiting the inflammation of the gut-brain axis
Barley 📋✍⛔36087390Effect of aqueous extract of barley and wheat grass in stress induced depression in Swiss mice
Bay Leaf 📋 ⛔37689325Neuroprotective and anti-amnesic effects of Laurus Nobilis essential oil against scopolamine-induced memory deficits in mice brain
Berries 📋 35217779Effect of berry-based supplements and foods on cognitive function: a systematic review
Beta-Alanine 📋✍⛔37758316Biochemical Mechanisms of Beneficial Effects of Beta-Alanine Supplements on Cognition
Beta-Cryptoxanthin 📋 32435993Higher maternal plasma β-cryptoxanthin concentration is associated with better cognitive and motor development in offspring at 2 years of age
Beta-Sitosterol 📋✍⛔34095883β-sitosterol reduces anxiety and synergizes with established anxiolytic drugs in mice
Bitter Orange 📋✍⛔29705445Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial
Black Pepper Essential Oil 📋 ⛔33997409Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum Linn. (Black pepper) in mice: involvement of serotonergic but not GABAergic transmission system
Bromelain 📋✍⛔37076960Effect of Bromelain on Chronic Unpredictable Stress-induced Behavioral, Biochemical, and Monoamine Changes in Wistar Albino Rat Model of Depression
Capsaicin 📋✍⛔35119578Capsaicinoid-Glucosides of Fresh Hot Pepper Promotes Stress Resistance and Longevity in Caenorhabditis elegans
Carnosol 📋 35973126Carnosol Reduced Pathogenic Protein Aggregation and Cognitive Impairment in Neurodegenerative Diseases Models via Improving Proteostasis and Ameliorating Mitochondrial Disorders
Cashew 📋 ⛔38002521Cashew ( Anacardium occidentale) Extract: Possible Effects on Hypothalamic-Pituitary-Adrenal (HPA) Axis in Modulating Chronic Stress
Cat's Claw 📋✍⛔33589649In vitro comparison of major memory-support dietary supplements for their effectiveness in reduction/inhibition of beta-amyloid protein fibrils and tau protein tangles: key primary targets for memory loss
Celery 📋 ⛔36334223Beneficial effects of celery seed extract (Apium graveolens), as a supplement, on anxiety and depression in hypertensive patients: a randomized clinical trial
Cheese 📋 ⛔38694223Association between cheese and fish consumption and the occurrence of depression based on European population: mediating role of metabolites
Cherry 📋 ⛔36181653Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop
Coptis Chinensis 📋 ⛔35173416Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis
Cryptotanshinone 📋 38011787Cryptotanshinone regulates gut microbiota and PI3K-AKT pathway in rats to alleviate CUMS induced depressive symptoms
Cyanidin 📋✍ 36254458Cyanidin Chloride Improves LPS-Induced Depression-Like Behavior in Mice by Ameliorating Hippocampal Inflammation and Excitotoxicity
Dandelion 📋✍⛔30636257Antidepressive Effects of Taraxacum Officinale in a Mouse Model of Depression Are Due to Inhibition of Corticosterone Levels and Modulation of Mitogen-Activated Protein Kinase Phosphatase-1 (Mkp-1) and Brain-Derived Neurotrophic Factor (Bdnf) Expression
Date 📋 ⛔35348229Antidepressant-like effects of aqueous extracts of miswak (Salvadora persica) and date palm (Phoenix dactylifera) on depression-like behaviors using CUMS model in male rats
DIM 📋✍⛔354618193,3'-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice
Egg 📋 ⛔37340479Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: a randomized double-blinded placebo-controlled parallel-group study
Emodin 📋 ⛔34381778Emodin Prevented Depression in Chronic Unpredicted Mild Stress-Exposed Rats by Targeting miR-139-5p/5-Lipoxygenase
Eucommia 📋✍⛔35664075Eucommiae cortex polysaccharides mitigate obesogenic diet-induced cognitive and social dysfunction via modulation of gut microbiota and tryptophan metabolism
Fat 📋 36986159Dietary Fats and Cognitive Status in Italian Middle-Old Adults
Fennel 📋✍⛔32491286Protective effect of fennel, and its major component trans-anethole against social isolation induced behavioral deficits in rats
Galangal 📋✍⛔32140977Alpinia oxyphylla-Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway
Ginger Essential Oil 📋✍ 19853815Effectiveness of the essential oils lavender and ginger in promoting children's comfort in a perianesthesia setting
Gingerol 📋✍ 336248466-Gingerol, an active constituent of ginger, attenuates lipopolysaccharide-induced oxidation, inflammation, cognitive deficits, neuroplasticity, and amyloidogenesis in rat
Guggulsterone 📋 28339691Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway
Hawthorn 📋✍⛔29893510Chlorogenic Acid from Hawthorn Berry (Crataegus pinnatifida Fruit) Prevents Stress Hormone-Induced Depressive Behavior, through Monoamine Oxidase B-Reactive Oxygen Species Signaling in Hippocampal Astrocytes of Mice
Helichrysum 📋 ⛔37570911Phytochemical Profiling, Antioxidant and Cognitive-Enhancing Effect of Helichrysum italicum ssp. italicum (Roth) G. Don (Asteraceae)
Hops 📋✍⛔35854340Humulus japonicus attenuates LPS-and scopolamine-induced cognitive impairment in mice
Hypericin 📋 37734259Novel antidepressant mechanism of hypericin: Role of connexin 43-based gap junctions
Iodine 📋✍⛔32802419The Relationship between Iodine and Selenium Levels with Anxiety and Depression in Patients with Euthyroid Nodular Goiter
Iron 📋✍⛔25837213Dietary intake of minerals in relation to depressive symptoms in Japanese employees: the Furukawa Nutrition and Health Study
Isoliquiritigenin 📋 32256666Isoliquiritigenin Attenuates Anxiety-Like Behavior and Locomotor Sensitization in Rats after Repeated Exposure to Nicotine
Isorhamnetin 📋 37754268Unraveling the Potential of Isorhamnetin as an Adjuvant in Depression Treatment with Escitalopram
Jasmine 📋 ⛔35010973Jasmine Tea Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior in Rats via the Gut-Brain Axis
Kava Root 📋✍⛔33207379Kava (Piper methysticum) Extract for the Treatment of Nervous Anxiety, Tension and Restlessness
L-Alanine 📋✍⛔33503956Phytochemical and Psychotropic Research of Motherwort ( Leonurus cardiaca L.) Modified Dry Extracts
L-Carnosine 📋✍⛔38664193Carnosine ameliorates postoperative cognitive dysfunction of aged rats by limiting astrocytes pyroptosis
L-Lysine 📋✍⛔35696944Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study
L-Tyrosine 📋✍⛔10023508A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria
Lecithin 📋✍⛔37009142Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination
Lemon Essential Oil 📋✍⛔35190270Effectiveness of lemon essential oil in reducing test anxiety in nursing students
Lemon Verbena 📋 ⛔35011093Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract
Ligustilide 📋 32065782Ligustilide improves aging-induced memory deficit by regulating mitochondrial related inflammation in SAMP8 mice
Liquiritin 📋 38074876Antidepressant effect of licorice total flavonoids and liquiritin: A review
Loquat 📋✍⛔37513484Dried Loquat Fruit Extract Containing Chlorogenic Acid Prevents Depressive-like Behaviors Induced by Repeated Corticosteroid Injections in Mice
Lotus 📋 ⛔32308703Nelumbo nucifera Gaertn Stems (Hegeng) Improved Depression Behavior in CUMS Mice by Regulating NCAM and GAP-43 Expression
Mango 📋 ⛔35344129Antidepressant activity of phytochemicals of Mangifera indica seeds assisted by integrated computational analysis
Mangosteen 📋✍⛔35415207Effects of water-soluble mangosteen extract on cognitive function and neuropsychiatric symptoms in patients with mild to moderate Alzheimer's disease (WECAN-AD): A randomized controlled trial
Myrtle 📋✍⛔33475094Myrtus communis improves cognitive impairment in renovascular hypertensive rats
NAD 📋 35956406Supplementation with NAD + and Its Precursors to Prevent Cognitive Decline across Disease Contexts
Neem 📋✍ 35198760Anxiolytic and antidepressant-like activities of aqueous extract of Azadirachta indica A. Juss. flower in the stressed rats
Neferine 📋 36120376Neferine alleviates chronic stress-induced depression by regulating monoamine neurotransmitter secretion and gut microbiota structure
Nutmeg 📋✍⛔35314522Mechanisms and safety of antidepressant-like effect of nutmeg in mice
Oleuropein 📋 30460087Oleuropein reduces anxiety-like responses by activating of serotonergic and neuropeptide Y (NPY)-ergic systems in a rat model of post-traumatic stress disorder
Oregano Essential Oil 📋✍⛔35201555A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats
Osmanthus 📋✍⛔38544932The inhalation effect of Osmanthus fragrans var. Aurantiacus on physiological parameters in chronically stressed rats
Parsley 📋 ⛔33916097The Potential of Parsley Polyphenols and Their Antioxidant Capacity to Help in the Treatment of Depression and Anxiety: An In Vivo Subacute Study
Peanut 📋 ⛔34656952Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial
Pear 📋 ⛔34602398Determination of anxiolytic and antidepressant like activity of hydro alcoholic fruit extract of Pyrus communis (L.) and its impact on the memory after chronic dosing in animal models
Perilla 📋✍ 37355083Antidepressant effect of Perilla frutescens essential oil through monoamine neurotransmitters and BDNF/TrkB signal pathway
Phloretin 📋 36793870Phloretin decreases microglia-mediated synaptic engulfment to prevent chronic mild stress-induced depression-like behaviors in the mPFC
Phytoestrogens 📋 ⛔37159774Role of Phytoestrogen in Menopausal Women With Depressive Symptoms: A Consecutive Case Series Study
Pistachio 📋✍⛔32529399Amelioration of motor and non-motor deficits and increased striatal APoE levels highlight the beneficial role of pistachio supplementation in rotenone-induced rat model of PD
Poria Mushrooms 📋✍ 35841662Integrated 16S rDNA, metabolomics, and TNF-α/NF-κB signaling pathway analyses to explain the modulatory effect of Poria cocos aqueous extract on anxiety-like behavior
PQQ 📋✍⛔35560363Safety and Efficacy of a Novel Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Functions in Healthy Volunteers: A Clinical Investigation
Pumpkin 📋 ⛔34336111L. Cucurbita pepo Alleviates Chronic Unpredictable Mild Stress via Modulation of Apoptosis, Neurogenesis, and Gliosis in Rat Hippocampus
Quinoa 📋 ⛔38337665The Neuroprotective Role of Quinoa ( Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats
Red Sage 📋✍⛔32827660Anxiolytic effect of an extract of Salvia miltiorrhiza Bunge (Danshen) in mice
Rose Essential Oil 📋 38492791Deciphering the antidepressant effects of Rosa damascena essential oil mediated through the serotonergic synapse signaling pathway
Safflower 📋✍⛔35198336The Use of Safflower (Carthamus tinctorius) in Treating Depression and Anxiety
Sesame Oil 📋 ⛔32276892A comparative neurobehavioral study of sesame oil and fish oil on experimental animals
Sesamin 📋✍ 35724814Alleviation of cognitive deficits via upregulation of chondroitin sulfate biosynthesis by lignan sesamin in a mouse model of neuroinflammation
Shogaol 📋 350366856-Shogaol Attenuates Traumatic Brain Injury-Induced Anxiety/Depression-like Behavior via Inhibition of Oxidative Stress-Influenced Expressions of Inflammatory Mediators TNF-α, IL-1β, and BDNF: Insight into the Mechanism
Spermidine 📋 38648866CaMKIIα mediates spermidine-induced memory enhancement in rats: A potential involvement of PKA/CREB pathway
Star Fuit 📋 ⛔30196278Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease
Tea Polyphenols 📋 38286317Targeting ERS-mitophagy in hippocampal neurons to explore the improvement of memory by tea polyphenols in aged type 2 diabetic rats
Theaflavins 📋✍ 30806570Anxiolytic effects of theaflavins via dopaminergic activation in the frontal cortex
Theobromine 📋✍⛔37121724Comparing Effects of Caffeine and Theobromine on Adrenal Hypertrophy and Social Behavior in Psychosocial Stressed Mice
Tongkat Ali 📋✍⛔30574050Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study
Tribulus Terrestris 📋✍⛔23789222Effect of tribulus terrestris saponins on behavior and neuroendocrine in chronic mild stress depression rats
Turmeric 📋✍⛔33946356Curcuma Longa, the "Golden Spice" to Counteract Neuroinflammaging and Cognitive Decline-What Have We Learned and What Needs to Be Done
Vitamin K 📋✍⛔37032783Association between vitamin K intake and depressive symptoms in US adults: Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2018
Vitamin K2 📋✍⛔28068285Vitamin K2 Improves Anxiety and Depression but Not Cognition in Rats With Metabolic Syndrome: A Role of Blood Glucose?
Vitamin K2 mk-7 📋✍ 37257737Neuroprotective effect of Vitamin K2 against gut dysbiosis associated cognitive decline
Vitamins 📋 36877601The role of vitamin D in depression and anxiety disorders: a review of the literature
Withanolides 📋 33424246Withametelin: a biologically active withanolide in cancer, inflammation, pain and depression
Wormwood 📋✍⛔36698740The effects of Artemisia absinthium L . on scopolamine-induced learning and memory impairment and brain tissue oxidative damage in adult rats
Yam 📋 32979168Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts
Zingerone 📋 35639359Protective Effects of Zingerone Against Depression-Like Behavior and Biochemical Changes in Chronic Stressed Rats: Antioxidant Effects
Aloe-Emodin 📋 36982280Effects of Aloe-Emodin on the Expression of Brain Aquaporins and Secretion of Neurotrophic Factors in a Rat Model of Post-Stroke Depression
Aloin 📋 30959371Aloin attenuates cognitive impairment and inflammation induced by d-galactose via down-regulating ERK, p38 and NF-κB signaling pathway
Alpha GPC 📋✍⛔27765578Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment
Apple Vinegar 📋✍⛔33084094Ameliorative effects of apple cider vinegar on neurological complications via regulation of oxidative stress markers
Apricot 📋 ⛔31550185Trans-Himalayan Phytococktail Confers Protection Against Hypobaric Hypoxia-Induced Hippocampal Neurodegeneration and Memory Impairment in Male Sprague Dawley Rats
Arctiin 📋 32609480Antidepressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- and TNF-α/TNFR1-Mediated NF-κB Activation
Arjuna 📋✍⛔28939021Terminalia arjuna bark extract attenuates picrotoxin-induced behavioral changes by activation of serotonergic, dopaminergic, GABAergic and antioxidant systems
Artemisinin 📋 38379899Artemisinin reduces PTSD-like symptoms, improves synaptic plasticity, and inhibits apoptosis in rats subjected to single prolonged stress
Avocado Oil 📋 ⛔33480081Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules
Balloon Flower 📋✍⛔33535469Platycodon grandiflorum Root Protects against Aβ-Induced Cognitive Dysfunction and Pathology in Female Models of Alzheimer's Disease
Bee Pollen 📋✍⛔34774703Bee pollen increases hippocampal brain-derived neurotrophic factor and suppresses neuroinflammation in adult rats with chronic immobilization stress
Bee Venom 📋✍⛔35448865Wasp Venom Ameliorates Scopolamine-Induced Learning and Memory Impairment in Mice
Bergamot 📋✍⛔30847114Efficacy of bergamot: From anti-inflammatory and anti-oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations
Bilberry 📋✍⛔31560462The influence of bilberry fruit on memory and the expression of parvalbumin in the rat hippocampus
Blackberry 📋 ⛔30892114Effect of blackberry juice ( Rubus fruticosus L.) on anxiety-like behaviour in Wistar rats
Boron 📋✍⛔7889884Dietary Boron, Brain Function, and Cognitive Performance
Butyrate 📋 ⛔35131015[Mechanisms of sodium butyrate inhibition of microglia inflammatory activation in hippocampus via Toll-like receptor 4/nuclear factor-κB p65 pathway]
Caffeic Acid 📋✍⛔33173990Effects of caffeic acid on epigenetics in the brain of rats with chronic unpredictable mild stress
Calcium 📋✍⛔25837213Dietary intake of minerals in relation to depressive symptoms in Japanese employees: the Furukawa Nutrition and Health Study
Camphor Essential Oil 📋 ⛔38621882[Essential oil of Cinnamomum camphora mitigates depression-like behavior in mice by regulating Nrf2/HO-1 pathway and inhibiting inflammatory cytokines]
Cantaloupe 📋 ⛔36967516Neuropharmacological evaluation of different species of Curcubitaceae seeds extract in experimental animals
CAPE 📋 36978961Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery
Carrot 📋 ⛔16755009Pharmacological evidence for the potential of Daucus carota in the management of cognitive dysfunctions
Chia Seeds 📋 ⛔38104182Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways
Chicoric Acid 📋 28003341Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB
Cinnamic Acid 📋 35325888Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice
Citral 📋 36322162Anxiolytic-like effects of citral in the mouse elevated plus maze: involvement of GABAergic and serotonergic transmissions
Clary Sage Essential Oil 📋✍⛔23444964Chronic food administration of Salvia sclarea oil reduces animals' anxious and dominant behavior
Clove Essential Oil 📋 ⛔37119836Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease
Copper 📋✍⛔35369103Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies
Coriander 📋 ⛔36076862Memory-Enhancing Effect of 8-Week Consumption of the Quercetin-Enriched Culinary Herbs-Derived Functional Ingredients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Coumaric acid 📋 38000530Protection of p-Coumaric acid against chronic stress-induced neurobehavioral deficits in mice via activating the PKA-CREB-BDNF pathway
Cranberry 📋✍⛔35662954Chronic Consumption of Cranberries ( Vaccinium macrocarpon) for 12 Weeks Improves Episodic Memory and Regional Brain Perfusion in Healthy Older Adults: A Randomised, Placebo-Controlled, Parallel-Groups Feasibility Study
Dairy 📋 35947163Associations between total dairy, high-fat dairy and low-fat dairy intake, and depressive symptoms: findings from a population-based cross-sectional study
Diallyl Disulfide 📋 33511484Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress
Dihydroartemisinin 📋 38552734Dihydroartemisinin protects mice from CUMS-induced depression-like behaviors and regulates gut microbes
Dioscin 📋 36077321Dioscorea nipponica Makino Rhizome Extract and Its Active Compound Dioscin Protect against Neuroinflammation and Scopolamine-Induced Memory Deficits
Diosmetin 📋 38460078Diosmetin Ameliorates HFD-induced Cognitive Impairments via Inhibiting Metabolic Disorders, Mitochondrial Dysfunction and Neuroinflammation in Male SD Rats
DMAE 📋✍⛔12844472Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states
Eggplant 📋 ⛔34994925Effect of Solanum vegetables on memory index, redox status, and expressions of critical neural genes in Drosophila melanogaster model of memory impairment
Elderberry 📋✍⛔25491608Antidepressant activities of Sambucus ebulus and Sambucus nigra
Eleuthero 📋✍⛔35262106Memory enhancement effect of saponins from Eleutherococcus senticosus leaves and blood-brain barrier-permeated saponins profiling using a pseudotargeted monitoring strategy
Equol 📋✍⛔34038497S-equol, a metabolite of dietary soy isoflavones, alleviates lipopolysaccharide-induced depressive-like behavior in mice by inhibiting neuroinflammation and enhancing synaptic plasticity
Essential Amino Acids 📋✍⛔34836128Deficiency in the Essential Amino Acids l-Isoleucine, l-Leucine and l-Histidine and Clinical Measures as Predictors of Moderate Depression in Elderly Women: A Discriminant Analysis Study
Eucalyptol 📋 35028340Baiap3 regulates depressive behaviors in mice via attenuating dense core vesicle trafficking in subsets of prefrontal cortex neurons
Fiber 📋✍⛔36692989Dietary fiber intake, depression, and anxiety: a systematic review and meta-analysis of epidemiologic studies
Fir Needle Oil 📋 ⛔36429972Relaxing Effects of Breathing Pseudotsuga menziesii and Lavandula angustifolia Essential Oils on Psychophysiological Status in Older Adults
Garlic Oil 📋 ⛔37435927Garlic essential oil ameliorates depression-like behaviors in unpredictable chronic mild stress by modulating the brain NLRP3 inflammasome pathway and influencing the gut barrier and microbiota
Ginger extract 📋✍⛔32051390Effect of combined extracts of aged garlic, ginger, and chili peppers on cognitive performance and brain antioxidant markers in Aβ-induced rats
Ginkgolic Acid 📋 27833555Ginkgolic Acid Protects against Aβ-Induced Synaptic Dysfunction in the Hippocampus
Glabridin 📋 23975867Potentiating effect of glabridin on GABAA receptor-mediated responses in dorsal raphe neurons
Glucosamine 📋✍⛔38673797Glucosamine Enhancement of Learning and Memory Functions by Promoting Fibroblast Growth Factor 21 Production
Glycine 📋✍⛔33503956Phytochemical and Psychotropic Research of Motherwort ( Leonurus cardiaca L.) Modified Dry Extracts
Grape Seed Oil 📋 ⛔32665902Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases
Grapefruit 📋 ⛔36500599Recovery of Naringin-Rich Flavonoid Extracts from Agroresidues with Anxiolytic- and Antidepressant-like Effects in Mice
Guava 📋 ⛔33034100Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain
HMB 📋✍⛔35268065Effects of β-Hydroxy β-Methylbutyrate Supplementation on Working Memory and Hippocampal Long-Term Potentiation in Rodents
Honeysuckle 📋 ⛔37863440Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice
Horsetail Grass 📋✍⛔21615059Anxiolytic Effects of Equisetum Arvense Linn. Extracts in Mice
Icaritin 📋 32714426Icaritin Improves Memory and Learning Ability by Decreasing BACE-1 Expression and the Bax/Bcl-2 Ratio in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice
Jujube 📋 ⛔35922734An aqueous macerate of Ziziphus jujuba reduces long-term spatial memory impairment in D-galactose treated rats: role of anti-inflammatory pathways
Kacip Fatimah 📋✍⛔20217640Protective effect of Labisia pumila on stress-induced behavioral, biochemical, and immunological alterations
L-Citrulline 📋✍⛔33940559Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease
L-Glutamine 📋✍⛔35786408Synergistic effects of Lacticaseibacillus rhamnosus GG, glutamine, and curcumin on chronic unpredictable mild stress-induced depression in a mouse model
L-Histidine 📋✍⛔34836128Deficiency in the Essential Amino Acids l-Isoleucine, l-Leucine and l-Histidine and Clinical Measures as Predictors of Moderate Depression in Elderly Women: A Discriminant Analysis Study
L-Methionine 📋✍⛔32564114Methionine Mediates Resilience to Chronic Social Defeat Stress by Epigenetic Regulation of NMDA Receptor Subunit Expression
Laminaria 📋✍⛔35394414Polysaccharides from laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation
Lemon Balm Essential Oil 📋✍⛔37207879The potential of lemon balm (Melissa officinalis L.) essential oil as an anti-anxiety agent - is the citronellal the activity carrier?
Lemongrass 📋✍⛔28499312Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-Like Activity of Cymbopogon citratus in Mice
Liquiritigenin 📋 28940173Liquiritigenin ameliorates memory and cognitive impairment through cholinergic and BDNF pathways in the mouse hippocampus
Maca Root 📋✍⛔24931003Maca reduces blood pressure and depression, in a pilot study in postmenopausal women
Madecassoside 📋 22841896Anxiolytic effects of standardized extract of Centella asiatica (ECa 233) after chronic immobilization stress in mice
Malvidin 📋 26235983Novel Application of Brain-Targeting Polyphenol Compounds in Sleep Deprivation-Induced Cognitive Dysfunction
Manganese 📋✍⛔35369103Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies
Mango Leaf 📋 ⛔32717999Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study
Marjoram 📋 ⛔33266220Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice
Milk Thistle 📋✍⛔28842342Phytochemical analysis, molecular docking and antiamnesic effects of methanolic extract of Silybum marianum (L.) Gaertn seeds in scopolamine induced memory impairment in mice
Minerals 📋 37108261Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression
Motherwort 📋✍⛔33503956Phytochemical and Psychotropic Research of Motherwort ( Leonurus cardiaca L.) Modified Dry Extracts
Mucuna Pruriens 📋✍⛔35747354Protective effects of Thai Mucuna pruriens (L.) DC. var. pruriens seeds on sexual behaviors and essential reproductive markers in chronic unpredictable mild stress mice
Myrrh 📋✍⛔26635888The Ameliorating Effect of Myrrh on Scopolamine-Induced Memory Impairments in Mice
Nattokinase 📋✍⛔37466380Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin
Nitrate 📋✍⛔37331149Habitual dietary nitrate intake and cognition in the Australian Imaging, Biomarkers and Lifestyle Study of ageing: A prospective cohort study
Noni 📋 ⛔36118093Effect of Noni on Memory Impairment Induced by Hydrocortisone in Mice
Oleic Acid 📋 ⛔34040528Combined Oral and Topical Application of Pumpkin ( Cucurbita pepo L.) Alleviates Contact Dermatitis Associated With Depression Through Downregulation Pro-Inflammatory Cytokines
Olive 📋✍⛔34796529Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke-induced depressive-like behaviors in Sprague-Dawley rats
Omega-9 Fatty Acids 📋 26780350The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice
Oolong Tea 📋 ⛔33575719Tea Consumption and Depression from Follow Up in the Singapore Longitudinal Ageing Study
Papaya 📋✍⛔24120519Evaluation of anxiolytic and sedative effects of 80% ethanolic Carica papaya L. (Caricaceae) pulp extract in mice
Parthenolide 📋 37182449Parthenolide alleviates microglia-mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder
Peach 📋 ⛔35598297Single-cell Transcriptomic Analysis Demonstrates the Regulation of Peach Polysaccharides on Circadian Rhythm Disturbance
Pine Needle Essential Oil 📋✍⛔33655878Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus
Pine Nut 📋 ⛔34269783Pine nut antioxidant peptides ameliorate the memory impairment in a scopolamine-induced mouse model via SIRT3-induced synaptic plasticity
Pomegranate Seed extract 📋 ⛔35348947Amelioration of oxidative stress, cholinergic dysfunction, and neuroinflammation in scopolamine-induced amnesic rats fed with pomegranate seed
Pregnenolone 📋✍⛔35108514Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
Progesterone 📋✍⛔38147491Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder - A Pilot Study
Pu-erh Tea 📋✍⛔32992081Pu'er tea water extract protects against cognitive impairment in a mouse model of lipopolysaccharide-induced neuroinflammation
Pueraria Mirifica 📋✍⛔26915634Neurotherapeutic Effects of Pueraria Mirifica Extract in Early- And Late-Stage Cognitive Impaired Rats
Pyridoxal-5-Phosphate 📋✍⛔30692033B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study
Rapamycin 📋✍ 37926147Rapamycin exerts an antidepressant effect and enhances myelination in the prefrontal cortex of chronic restraint stress mice
Raspberry 📋✍⛔31328696Red raspberry ( Rubus ideaus) supplementation mitigates the effects of a high-fat diet on brain and behavior in mice
Red Yeast Rice 📋✍⛔34048842Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation
Rehmannia 📋✍⛔35091012Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia
Rice 📋 ⛔37375622Rice Germ Attenuates Chronic Unpredictable Mild Stress-Induced Muscle Atrophy
Royal Jelly 📋✍⛔32329707Chronic Royal Jelly Administration Induced Antidepressant-Like Effects Through Increased Sirtuin1 and Oxidative Phosphorylation Protein Expression in the Amygdala of Mice
Sea Cucumber 📋 38369274Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification
Shiitake Mushrooms 📋✍⛔33541370β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis
Shilajit 📋✍⛔22482077Shilajit: a natural phytocomplex with potential procognitive activity
Soy 📋✍⛔36117647Soy product consumption and the risk of major depressive disorder in older adults: Evidence from a cohort study
Soy Protein 📋✍⛔36514948Soy protein increases cognitive level in mice by modifying hippocampal nerve growth, oxidative stress and intestinal microbiota
Star Anise 📋✍⛔24919985Anxiolytic-like effect of Illicium verum fruit oil, trans-anethole and related compounds in mice
Stigmasterol 📋 22173129The ameliorating effects of stigmasterol on scopolamine-induced memory impairments in mice
Strawberry 📋✍⛔28790915Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f
Sweet Potato 📋 ⛔35720655Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction
Tannic Acid 📋✍⛔35792271Tannic acid inhibits lipopolysaccharide-induced cognitive impairment in adult mice by targeting multiple pathological features
Telmisartan 📋 ⛔34547248Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations
Tetrahydrocurcumin 📋✍ 35723652Tetrahydrocurcumin Ameliorates Acute Hypobaric Hypoxia-Induced Cognitive Impairment in Mice
Thyme Essential Oil 📋 ⛔33158153Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems
Tomato 📋 ⛔25880734Tomato juice intake increases resting energy expenditure and improves hypertriglyceridemia in middle-aged women: an open-label, single-arm study
Turkey Tail Mushrooms 📋 ⛔34764755Deciphering the CNS anti-depressant, antioxidant and cytotoxic profiling of methanol and aqueous extracts of Trametes versicolor and molecular interactions of its phenolic compounds
Ursolic Acid 📋✍⛔37541369Effects of oleanolic acid and ursolic acid on depression-like behaviors induced by maternal separation in mice
Vegetables 📋 35307760Associations of specific types of fruit and vegetables with perceived stress in adults: the AusDiab study
Vitamin A 📋✍⛔35548582Associations of Dietary Vitamin A and Beta-Carotene Intake With Depression. A Meta-Analysis of Observational Studies
Vitamin B5 📋✍⛔31691401The potential role of B5: A stitch in time and switch in cytokine
Vitamin B7 📋✍⛔33171595PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression-A Randomized Controlled Trial
Wasabi 📋 ⛔37960261Benefits of Wasabi Supplements with 6-MSITC (6-Methylsulfinyl Hexyl Isothiocyanate) on Memory Functioning in Healthy Adults Aged 60 Years and Older: Evidence from a Double-Blinded Randomized Controlled Trial
Whey Protein 📋✍⛔38137233Protective Effects of Whey Protein Hydrolysate, Treadmill Exercise, and Their Combination against Scopolamine-Induced Cognitive Deficit in Mice
White Mushrooms 📋 ⛔36291298White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease
Wogonin 📋✍⛔12392823Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi
Yohimbine 📋✍ 34889886Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments